🗊Презентация Environmental risk assessment

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Environmental risk assessment, слайд №1Environmental risk assessment, слайд №2Environmental risk assessment, слайд №3Environmental risk assessment, слайд №4Environmental risk assessment, слайд №5Environmental risk assessment, слайд №6Environmental risk assessment, слайд №7Environmental risk assessment, слайд №8Environmental risk assessment, слайд №9Environmental risk assessment, слайд №10Environmental risk assessment, слайд №11Environmental risk assessment, слайд №12Environmental risk assessment, слайд №13Environmental risk assessment, слайд №14Environmental risk assessment, слайд №15Environmental risk assessment, слайд №16Environmental risk assessment, слайд №17Environmental risk assessment, слайд №18Environmental risk assessment, слайд №19Environmental risk assessment, слайд №20Environmental risk assessment, слайд №21Environmental risk assessment, слайд №22Environmental risk assessment, слайд №23Environmental risk assessment, слайд №24Environmental risk assessment, слайд №25Environmental risk assessment, слайд №26Environmental risk assessment, слайд №27Environmental risk assessment, слайд №28Environmental risk assessment, слайд №29Environmental risk assessment, слайд №30Environmental risk assessment, слайд №31

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Environmental risk assessment
Описание слайда:
Environmental risk assessment

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Definition

The term “environmental risk” is used widely:
environmental risk is sometimes used as a synonym for environmental impact
environmental risk is sometimes also used as a risk that corporate activities exert on the environment
environmental risks are defined as risks with the potential to fundamentally disrupt the stability of the Earth’s systems 
risk itself is defined as the combination of the probability of an event and its negative consequences
Описание слайда:
Definition The term “environmental risk” is used widely: environmental risk is sometimes used as a synonym for environmental impact environmental risk is sometimes also used as a risk that corporate activities exert on the environment environmental risks are defined as risks with the potential to fundamentally disrupt the stability of the Earth’s systems risk itself is defined as the combination of the probability of an event and its negative consequences

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By their nature, environmental risks are characterized by 

spatial propagation, 
time-lag occurrence, 
multiplier effects, 
accumulation,
and irreversibility
interconnectedness
Описание слайда:
By their nature, environmental risks are characterized by spatial propagation, time-lag occurrence, multiplier effects, accumulation, and irreversibility interconnectedness

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Environmental risk assessment, слайд №4
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Environmental risk trade-offs 
It is estimated that in 2010 there were 219 million cases of infection, of which 79 % occurred in Africa.
 A total of 660,000 people were killed, with the death toll in Africa accounting for 90 % of these.
 DDT is considered to be the most cost-effective insecticide for containing malaria
DDT’s stigma was made known to the world by Rachel Carson’s “Silent Spring,” published in 1962. 
On the other hand, in 2006, the World Health Organisation (WHO) reversed nearly 30 years of policies restraining the use of DDT and instead endorsed DDT use for indoor residual spraying (IRS) in epidemic areas as well as in areas with constant and high malaria transmission.
Описание слайда:
Environmental risk trade-offs It is estimated that in 2010 there were 219 million cases of infection, of which 79 % occurred in Africa. A total of 660,000 people were killed, with the death toll in Africa accounting for 90 % of these. DDT is considered to be the most cost-effective insecticide for containing malaria DDT’s stigma was made known to the world by Rachel Carson’s “Silent Spring,” published in 1962. On the other hand, in 2006, the World Health Organisation (WHO) reversed nearly 30 years of policies restraining the use of DDT and instead endorsed DDT use for indoor residual spraying (IRS) in epidemic areas as well as in areas with constant and high malaria transmission.

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Environmental risk assessment, слайд №6
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Risk analysis
Risk analysis allows us to estimate impacts on the environment and on human health when we have not measured or cannot measure or directly observe those impacts. It also lets us compare these impacts. In this chapter, we introduce the concept of risk analysis and risk management. The former is the measurement and comparison of various forms of risk; the latter involves the techniques used to reduce these risks.
Описание слайда:
Risk analysis Risk analysis allows us to estimate impacts on the environment and on human health when we have not measured or cannot measure or directly observe those impacts. It also lets us compare these impacts. In this chapter, we introduce the concept of risk analysis and risk management. The former is the measurement and comparison of various forms of risk; the latter involves the techniques used to reduce these risks.

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In general, a risk factor should meet the following conditions: 

Exposure to the risk factor precedes appearance of the adverse effect.
The risk factor and the adverse effect are consistently associated. That is, the adverse effect is not usually observed in the absence of the risk factor.
The more of the risk factor there is, or the greater its intensity, the greater the adverse effect, although the functional relationship need not be linear or monotonic.
The occurrence or magnitude of the adverse effect is statistically significantly greater in the presence of the risk factor than in its absence.
Описание слайда:
In general, a risk factor should meet the following conditions: Exposure to the risk factor precedes appearance of the adverse effect. The risk factor and the adverse effect are consistently associated. That is, the adverse effect is not usually observed in the absence of the risk factor. The more of the risk factor there is, or the greater its intensity, the greater the adverse effect, although the functional relationship need not be linear or monotonic. The occurrence or magnitude of the adverse effect is statistically significantly greater in the presence of the risk factor than in its absence.

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Risk assessment is a system of analysis that includes four tasks:

1. Identification of a substance (a toxicant) that may have adverse health effects
2. Scenarios for exposure to the toxicant
3. Characterization of health effects
4. An estimate of the probability (risk) of occurrence of these health effects
Описание слайда:
Risk assessment is a system of analysis that includes four tasks: 1. Identification of a substance (a toxicant) that may have adverse health effects 2. Scenarios for exposure to the toxicant 3. Characterization of health effects 4. An estimate of the probability (risk) of occurrence of these health effects

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Toxicants are usually identified when an associated adverse health effect is noticed. 
In most cases, the first intimation that a substance is toxic is its association with an unusual number of deaths. 
Mortality risk, or risk of death, is easier to determine for populations, especially in the developed countries, than morbidity risk (risk of illness) because all deaths and their apparent causes are reported on death certificates, while recording of disease incidence, which began in the relatively recent past, is done only for a very few diseases. Death certificate data may be misleading: An individual who suffers from high blood pressure but is killed in an automobile accident becomes an accident statistic rather than a cardiovascular disease statistic. In addition, occupational mortality risks are well documented only for men; until the present generation, too few women worked outside the home all their lives to form a good statistical base.
Описание слайда:
Toxicants are usually identified when an associated adverse health effect is noticed. In most cases, the first intimation that a substance is toxic is its association with an unusual number of deaths. Mortality risk, or risk of death, is easier to determine for populations, especially in the developed countries, than morbidity risk (risk of illness) because all deaths and their apparent causes are reported on death certificates, while recording of disease incidence, which began in the relatively recent past, is done only for a very few diseases. Death certificate data may be misleading: An individual who suffers from high blood pressure but is killed in an automobile accident becomes an accident statistic rather than a cardiovascular disease statistic. In addition, occupational mortality risks are well documented only for men; until the present generation, too few women worked outside the home all their lives to form a good statistical base.

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The risk assessment process consists of four basic steps:

Hazard identification—Defining the hazard and nature of the harm; for example, identifying a chemical contaminant, such as lead or carbon tetrachloride, and documenting its toxic effects on human beings.
Exposure assessment—Determining the concentration of a contaminating agent in the environment and estimating its rate of intake in target organisms; for example, finding the concentration of aflatoxin (a fungal toxin) in peanut butter and determining the dose an ‘‘average’’ person would receive.
 Dose–response assessment—Quantitating the adverse effects arising from exposure to a hazardous agent based on the degree of exposure. This assessment is usually expressed mathematically as a plot showing a response (i.e., mortality) in living organisms to increasing doses of the agent.
Risk characterization—Estimating the potential impact of a hazard based on the severity of its effects and the amount of exposure
Описание слайда:
The risk assessment process consists of four basic steps: Hazard identification—Defining the hazard and nature of the harm; for example, identifying a chemical contaminant, such as lead or carbon tetrachloride, and documenting its toxic effects on human beings. Exposure assessment—Determining the concentration of a contaminating agent in the environment and estimating its rate of intake in target organisms; for example, finding the concentration of aflatoxin (a fungal toxin) in peanut butter and determining the dose an ‘‘average’’ person would receive. Dose–response assessment—Quantitating the adverse effects arising from exposure to a hazardous agent based on the degree of exposure. This assessment is usually expressed mathematically as a plot showing a response (i.e., mortality) in living organisms to increasing doses of the agent. Risk characterization—Estimating the potential impact of a hazard based on the severity of its effects and the amount of exposure

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Environmental risk assessment, слайд №12
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DOSE-RESPONSE EVALUATION

Dose-response evaluation is required both in determining exposure scenarios for the pollutant in question and in characterizing a health effect. The response of an organism to a pollutant always depends in some way on the amount or dose of pollutant to the organism. The magnitude of the dose, in turn, depends on the exposure pathway. The same substance may have a different effect depending on whether it is inhaled, ingested, or absorbed through the skin, or whether the exposure is external. The exposure pathway determines the biochemistry of the pollutant in the organism. In general, the human body detoxifies an ingested pollutant more efficiently than it does an inhaled pollutant.
Описание слайда:
DOSE-RESPONSE EVALUATION Dose-response evaluation is required both in determining exposure scenarios for the pollutant in question and in characterizing a health effect. The response of an organism to a pollutant always depends in some way on the amount or dose of pollutant to the organism. The magnitude of the dose, in turn, depends on the exposure pathway. The same substance may have a different effect depending on whether it is inhaled, ingested, or absorbed through the skin, or whether the exposure is external. The exposure pathway determines the biochemistry of the pollutant in the organism. In general, the human body detoxifies an ingested pollutant more efficiently than it does an inhaled pollutant.

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Possible dose-response curve
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Possible dose-response curve

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Some characteristic features of the dose-response relationship are:

Threshold.  The existence of a threshold in health effects of pollutants has been debated for many years. A threshold dose is the lowest dose at which there is an observable effect. 
Total body burden.  An organism, or a person, can be exposed simultaneously to several different sources of a given pollutant. For example, we may inhale about 50 ~g/day of lead from the ambient air and ingest about 300~g/day in food and water. The concentration of lead in the body is thus the sum of what is inhaled and ingested and what remains in the body from prior exposure, less what has been eliminated from the body. This sum is the total body burden of the pollutant.
Physiological half-life.  The physiological half-life of a pollutant in an organism is the time needed for the organism to eliminate half of the internal concentration of the pollutant, through metabolism or other normal physiological functions.
Bioaccumulation and bioconcentration.  Bioaccumulation occurs when a substance is concentrated in one organ or type of tissue of an organism.
Описание слайда:
Some characteristic features of the dose-response relationship are: Threshold. The existence of a threshold in health effects of pollutants has been debated for many years. A threshold dose is the lowest dose at which there is an observable effect. Total body burden. An organism, or a person, can be exposed simultaneously to several different sources of a given pollutant. For example, we may inhale about 50 ~g/day of lead from the ambient air and ingest about 300~g/day in food and water. The concentration of lead in the body is thus the sum of what is inhaled and ingested and what remains in the body from prior exposure, less what has been eliminated from the body. This sum is the total body burden of the pollutant. Physiological half-life. The physiological half-life of a pollutant in an organism is the time needed for the organism to eliminate half of the internal concentration of the pollutant, through metabolism or other normal physiological functions. Bioaccumulation and bioconcentration. Bioaccumulation occurs when a substance is concentrated in one organ or type of tissue of an organism.

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Bioconcentration of DDT
A study of the Lake Michigan ecosystem found the following bioconcentration of DDT: 
0.014 ppm (wet weight) in bottom sediments
0.41 ppm in bottom-feeding crustacea
3 to 6 ppm in fish
2400 ppm in fish-eating birds
Описание слайда:
Bioconcentration of DDT A study of the Lake Michigan ecosystem found the following bioconcentration of DDT: 0.014 ppm (wet weight) in bottom sediments 0.41 ppm in bottom-feeding crustacea 3 to 6 ppm in fish 2400 ppm in fish-eating birds

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Some characteristic features of the dose-response relationship are:

5. Exposure time  and  time vs. dosage.  Most pollutants need time to react; the exposure time is thus as important as the level of exposure. 
6. Synergism.  Synergism occurs when two or more substances enhance each other's effects, and when the resulting effect of the combination on the organism is greater than the additive effects of the substances separately. 
7. LC5o  and  LD50.  Dose-response relationships for human health are usually determined from health data or epidemiological studies. Human volunteers obviously cannot be subjected to pollutant doses that produce major or lasting health effects, let alone fatal doses. Toxicity can be determined, however, by subjecting nonhuman organisms to increasing doses of a pollutant until the organism dies. The LD50 is the dose that is lethal for 50% of the experimental animals used; LC50 refers to lethal concentration rather than lethal dose. LD50 values are most useful in comparing toxicities, as for pesticides and agricultural chemicals; no direct extrapolation is possible, either to humans or to any species other than the one used for the LD50 determination. LD50 can sometimes be determined retrospectively when a large population has been exposed accidentally, as in the accident at the Chernobyl nuclear reactor.
Описание слайда:
Some characteristic features of the dose-response relationship are: 5. Exposure time and time vs. dosage. Most pollutants need time to react; the exposure time is thus as important as the level of exposure. 6. Synergism. Synergism occurs when two or more substances enhance each other's effects, and when the resulting effect of the combination on the organism is greater than the additive effects of the substances separately. 7. LC5o and LD50. Dose-response relationships for human health are usually determined from health data or epidemiological studies. Human volunteers obviously cannot be subjected to pollutant doses that produce major or lasting health effects, let alone fatal doses. Toxicity can be determined, however, by subjecting nonhuman organisms to increasing doses of a pollutant until the organism dies. The LD50 is the dose that is lethal for 50% of the experimental animals used; LC50 refers to lethal concentration rather than lethal dose. LD50 values are most useful in comparing toxicities, as for pesticides and agricultural chemicals; no direct extrapolation is possible, either to humans or to any species other than the one used for the LD50 determination. LD50 can sometimes be determined retrospectively when a large population has been exposed accidentally, as in the accident at the Chernobyl nuclear reactor.

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POPULATION  RESPONSES

Individual responses to a particular pollutant may differ widely; dose-response relationships differ from one individual to another. In particular, thresholds differ; threshold values in a population, however, generally follow a Gaussian distribution.
Описание слайда:
POPULATION RESPONSES Individual responses to a particular pollutant may differ widely; dose-response relationships differ from one individual to another. In particular, thresholds differ; threshold values in a population, however, generally follow a Gaussian distribution.

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Distribution of odor thresholds in a population
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Distribution of odor thresholds in a population

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Individual responses and thresholds also depend on age, sex, and general state of physical and emotional health. 
there is no release level for which protection can be ensured for everyone, so a comparative risk analysis is necessary. Carcinogens are all considered to be in this category of nonthreshold pollutants.
Описание слайда:
Individual responses and thresholds also depend on age, sex, and general state of physical and emotional health. there is no release level for which protection can be ensured for everyone, so a comparative risk analysis is necessary. Carcinogens are all considered to be in this category of nonthreshold pollutants.

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EXPOSURE AND LATENCY

Characterization of some health risks can take a very long time
There is a growing tendency to regulate any substance for which there is any evidence, even inconclusive, of adverse health effects. 
The cost of such control has recently been determined to be far greater than the cost of treating or mitigating the effect.  3  For example, vinyl chloride emission control is estimated to cost 1.6 million dollars per year of life saved, while leukemia treatment by bone marrow transplant costs $12,000 per year of life saved.
Описание слайда:
EXPOSURE AND LATENCY Characterization of some health risks can take a very long time There is a growing tendency to regulate any substance for which there is any evidence, even inconclusive, of adverse health effects. The cost of such control has recently been determined to be far greater than the cost of treating or mitigating the effect. 3 For example, vinyl chloride emission control is estimated to cost 1.6 million dollars per year of life saved, while leukemia treatment by bone marrow transplant costs $12,000 per year of life saved.

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EXPRESSION OF RISK
Risk is defined as the product of probability and consequence, and is expressed as the probability or frequency of occurrence of an undesirable event. It is important to note that  both  probability and consequence must play a role in risk assessment. Arguments over pollution control often concentrate on consequence alone; members of the public fear a consequence (like the Bhopal isocyanate release) irrespective of its remote likelihood or low frequency of occurrence. However, pollution control decisions, like other risk-based decisions, cannot be made on the basis of consequence alone
Описание слайда:
EXPRESSION OF RISK Risk is defined as the product of probability and consequence, and is expressed as the probability or frequency of occurrence of an undesirable event. It is important to note that both probability and consequence must play a role in risk assessment. Arguments over pollution control often concentrate on consequence alone; members of the public fear a consequence (like the Bhopal isocyanate release) irrespective of its remote likelihood or low frequency of occurrence. However, pollution control decisions, like other risk-based decisions, cannot be made on the basis of consequence alone

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EXPRESSION OF RISK
An expression of risk incorporates both the probability and some measure of consequence. In discussing human health or environmental risk, the consequences are adverse health effects or adverse effects on some species of plant or animal. Challenges to the linear nonthreshold theory of carcinogenesis have been raised recently, particularly with respect to the effects of ionizing radiation.
Описание слайда:
EXPRESSION OF RISK An expression of risk incorporates both the probability and some measure of consequence. In discussing human health or environmental risk, the consequences are adverse health effects or adverse effects on some species of plant or animal. Challenges to the linear nonthreshold theory of carcinogenesis have been raised recently, particularly with respect to the effects of ionizing radiation.

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The  probability,  or frequency of occurrence, of adverse health effects in a population is written as                       P = X / N
  where  P = probability
X = number of adverse health effects
N = number of individuals in the population
Описание слайда:
The probability, or frequency of occurrence, of adverse health effects in a population is written as P = X / N where P = probability X = number of adverse health effects N = number of individuals in the population

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Relative risk
Relative risk  is the ratio of the probabilities that an adverse effect will occur in two different populations. For example, the relative risk of fatal lung cancer in smokers may be expressed as
 
	Ps/Pn = (Xs/Ns) / (Xn /Nn)
 
where  Ps - probability of fatal lung cancer in smokers
Pn -  probability of fatal lung cancer in nonsmokers
Xs = fatal lung cancer in smokers
Xn - fatal lung cancer in nonsmokers
Ns = total number of smokers
N n =  total number of nonsmokers
Описание слайда:
Relative risk Relative risk is the ratio of the probabilities that an adverse effect will occur in two different populations. For example, the relative risk of fatal lung cancer in smokers may be expressed as   Ps/Pn = (Xs/Ns) / (Xn /Nn)   where Ps - probability of fatal lung cancer in smokers Pn - probability of fatal lung cancer in nonsmokers Xs = fatal lung cancer in smokers Xn - fatal lung cancer in nonsmokers Ns = total number of smokers N n = total number of nonsmokers

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Relative risk of death is also called the  standard mortality ratio  (SMR), which is written as
SMR = Ds/Dn = Ps / Pn
where  Ds = observed lung cancer deaths in a population of habitual smokers
Dn - expected lung cancer deaths in a nonsmoking population of the same size
Описание слайда:
Relative risk of death is also called the standard mortality ratio (SMR), which is written as SMR = Ds/Dn = Ps / Pn where Ds = observed lung cancer deaths in a population of habitual smokers Dn - expected lung cancer deaths in a nonsmoking population of the same size

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In this particular instance, the SMR is approximately 11/1 and is significantly greater than 1. 
Three important characteristics of epidemiological reasoning are illustrated by this example:
• Everyone who smokes heavily will not die of lung cancer.
• Some nonsmokers die of lung cancer.
• Therefore, one cannot unequivocally relate any given individual lung cancer death to cigarette smoking.
Описание слайда:
In this particular instance, the SMR is approximately 11/1 and is significantly greater than 1. Three important characteristics of epidemiological reasoning are illustrated by this example: • Everyone who smokes heavily will not die of lung cancer. • Some nonsmokers die of lung cancer. • Therefore, one cannot unequivocally relate any given individual lung cancer death to cigarette smoking.

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Risk may be expressed in several ways:

 Deaths per 100,000 persons.  In 1985 in the United States, 350,000 smokers died as a result of lung cancer and heart disease. In that year, the United States had a population of 226 million. The risk of death (from these two factors) associated with habitual smoking may thus be expressed as deaths per 100,000 population, or
 
(350000 * 100000) / 226* 106 = 155 
 
in other words, a habitual smoker in the United States has an annual risk of 155 in 100,000, or 1.55 in 1000, of dying of lung cancer or heart disease. The probability is 1.55 in 1000; the consequence is death from lung cancer or heart disease.
Описание слайда:
Risk may be expressed in several ways: Deaths per 100,000 persons. In 1985 in the United States, 350,000 smokers died as a result of lung cancer and heart disease. In that year, the United States had a population of 226 million. The risk of death (from these two factors) associated with habitual smoking may thus be expressed as deaths per 100,000 population, or   (350000 * 100000) / 226* 106 = 155   in other words, a habitual smoker in the United States has an annual risk of 155 in 100,000, or 1.55 in 1000, of dying of lung cancer or heart disease. The probability is 1.55 in 1000; the consequence is death from lung cancer or heart disease.

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Environmental risk assessment, слайд №29
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 Deaths per 1000 deaths.  Using 1985 data again, there were 2,084,000 deaths in the United States that year. Of these, 350,000, or 168 deaths per 1000 deaths, were related to habitual smoking. 
 Loss of years of life or, for occupational risks, loss of work days or work years.  Loss of years of life depends on life expectancy, which differs considerably from one country to another. Average life expectancy in the United States is now 75 years; in Canada, 76.3 years; and in Ghana, 54 years.
Описание слайда:
Deaths per 1000 deaths. Using 1985 data again, there were 2,084,000 deaths in the United States that year. Of these, 350,000, or 168 deaths per 1000 deaths, were related to habitual smoking. Loss of years of life or, for occupational risks, loss of work days or work years. Loss of years of life depends on life expectancy, which differs considerably from one country to another. Average life expectancy in the United States is now 75 years; in Canada, 76.3 years; and in Ghana, 54 years.

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