🗊Презентация Nano-enabled biological tissues

Категория: Технология
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Nano-enabled biological tissues, слайд №1Nano-enabled biological tissues, слайд №2Nano-enabled biological tissues, слайд №3Nano-enabled biological tissues, слайд №4Nano-enabled biological tissues, слайд №5Nano-enabled biological tissues, слайд №6Nano-enabled biological tissues, слайд №7Nano-enabled biological tissues, слайд №8Nano-enabled biological tissues, слайд №9Nano-enabled biological tissues, слайд №10Nano-enabled biological tissues, слайд №11Nano-enabled biological tissues, слайд №12Nano-enabled biological tissues, слайд №13Nano-enabled biological tissues, слайд №14Nano-enabled biological tissues, слайд №15Nano-enabled biological tissues, слайд №16Nano-enabled biological tissues, слайд №17
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Вы можете ознакомиться и скачать презентацию на тему Nano-enabled biological tissues. Доклад-сообщение содержит 17 слайдов. Презентации для любого класса можно скачать бесплатно. Если материал и наш сайт презентаций Mypresentation Вам понравились – поделитесь им с друзьями с помощью социальных кнопок и добавьте в закладки в своем браузере.

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Nano-enabled Biological Tissues By Bradly Alicea http://www.msu.edu/~aliceabr/ Presented to PHY 913 (Nanotechnology and Nanosystems, Michigan State University). October, 2010.
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Nano-enabled Biological Tissues By Bradly Alicea http://www.msu.edu/~aliceabr/ Presented to PHY 913 (Nanotechnology and Nanosystems, Michigan State University). October, 2010.

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Nanoscale Technology Enables Complexity at Larger Scales…….
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Nanoscale Technology Enables Complexity at Larger Scales…….

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Role of Scale (Size AND Organization)
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Role of Scale (Size AND Organization)

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Ingredient I, Biomimetics/ Biocompatibility Biomimetics: engineering design that mimics natural systems. Nature has evolved things better than humans can design them. * can use biological materials (silks) or structures (synapses). Biocompatibility: materials that do not interfere with biological function. * compliant materials used to replace skin, connective tissues. * non-toxic polymers used to prevent inflammatory response in implants.
Описание слайда:
Ingredient I, Biomimetics/ Biocompatibility Biomimetics: engineering design that mimics natural systems. Nature has evolved things better than humans can design them. * can use biological materials (silks) or structures (synapses). Biocompatibility: materials that do not interfere with biological function. * compliant materials used to replace skin, connective tissues. * non-toxic polymers used to prevent inflammatory response in implants.

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Artificial Skin, Two Approaches
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Artificial Skin, Two Approaches

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Artificial Skin – Response Characteristics Results for stimulation of electronic skin: Output signal from electronic skin, representation is close to pressure stimulus. * only produces one class of sensory information (pressure, mechanical). Q: does artificial skin replicate neural coding? * patterned responses over time (rate-coding) may be possible. * need local spatial information (specific to an area a few sensors wide). * need for intelligent systems control theory at micro-, nano-scale.
Описание слайда:
Artificial Skin – Response Characteristics Results for stimulation of electronic skin: Output signal from electronic skin, representation is close to pressure stimulus. * only produces one class of sensory information (pressure, mechanical). Q: does artificial skin replicate neural coding? * patterned responses over time (rate-coding) may be possible. * need local spatial information (specific to an area a few sensors wide). * need for intelligent systems control theory at micro-, nano-scale.

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Silk as Substrate, Two Approaches
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Silk as Substrate, Two Approaches

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Ingredient II, Flexible Electronics Q: how do we incorporate the need for compliance in a device that requires electrical functionality? * tissues need to bend, absorb externally-applied loads, conform to complex geometries, dissipate energy. A: Flexible electronics (flexible polymer as a substrate).
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Ingredient II, Flexible Electronics Q: how do we incorporate the need for compliance in a device that requires electrical functionality? * tissues need to bend, absorb externally-applied loads, conform to complex geometries, dissipate energy. A: Flexible electronics (flexible polymer as a substrate).

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E-skin for Applications Organic field effect transistors (OFETs): * use polymers with semiconducting properties. Thin-film Transistors (TFTs): * semiconducting, dielectric layers and contacts on non-Si substrate (e.g. LCD technology). * in flexible electronics, substrate is a compliant material (skeleton for electronic array).
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E-skin for Applications Organic field effect transistors (OFETs): * use polymers with semiconducting properties. Thin-film Transistors (TFTs): * semiconducting, dielectric layers and contacts on non-Si substrate (e.g. LCD technology). * in flexible electronics, substrate is a compliant material (skeleton for electronic array).

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Ingredient III, Nanopatterning Q: how do we get cells in culture to form complex geometries?
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Ingredient III, Nanopatterning Q: how do we get cells in culture to form complex geometries?

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MWCNTs as Substrate for Neurons Multi-Wall CNT substrate for HC neurons: Nano Letters, 5(6), 1107-1110 (2005).
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MWCNTs as Substrate for Neurons Multi-Wall CNT substrate for HC neurons: Nano Letters, 5(6), 1107-1110 (2005).

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Bottom-up vs. Top-down Approaches
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Bottom-up vs. Top-down Approaches

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Top-down approach: Electrospinning Align nanofibers using electrostatic repulsion forces (review, see Biomedical Materials, 3, 034002 - 2008). Contact guidance theory: Cells tend to migrate along orientations associated with chemical, structural, mechanical properties of substrate.
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Top-down approach: Electrospinning Align nanofibers using electrostatic repulsion forces (review, see Biomedical Materials, 3, 034002 - 2008). Contact guidance theory: Cells tend to migrate along orientations associated with chemical, structural, mechanical properties of substrate.

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Bottom-up approach: Molecular Self-assembly Protein and peptide approaches commonly used. Protein approach – see review, Progress in Materials Science, 53, 1101–1241 (2008).
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Bottom-up approach: Molecular Self-assembly Protein and peptide approaches commonly used. Protein approach – see review, Progress in Materials Science, 53, 1101–1241 (2008).

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Additional Tools: Memristor Memristor: information-processing device (memory + resistor, Si-based) at nanoscale. * conductance incrementally modified by controlling change, demonstrates short-term potentiation (biological synapse-like).
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Additional Tools: Memristor Memristor: information-processing device (memory + resistor, Si-based) at nanoscale. * conductance incrementally modified by controlling change, demonstrates short-term potentiation (biological synapse-like).

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Additional Tools: Bioprinting Bioprinting: inkjet printers can deposit layers on a substrate in patterned fashion. * 3D printers (rapid prototypers) can produce a complex geometry (see Ferrari, M., “BioMEMS and Biomedical Nanotechnology”, 2006).
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Additional Tools: Bioprinting Bioprinting: inkjet printers can deposit layers on a substrate in patterned fashion. * 3D printers (rapid prototypers) can produce a complex geometry (see Ferrari, M., “BioMEMS and Biomedical Nanotechnology”, 2006).

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Conclusions Nano can play a fundamental role in the formation of artificial tissues, especially when considering: * emergent processes: in development, all tissues and organs emerge from a globe of stem cells. * merging the sensory (electrical) and biomechanical (material properties) aspects of a tissue. Advances in nanotechnology might also made within this problem domain. * scaffold design requires detailed, small-scale substrates (for mechanical support, nutrient delivery). * hybrid protein-carbon structures, or more exotic “biological” solutions (reaction-diffusion models, natural computing, Artificial Life)?
Описание слайда:
Conclusions Nano can play a fundamental role in the formation of artificial tissues, especially when considering: * emergent processes: in development, all tissues and organs emerge from a globe of stem cells. * merging the sensory (electrical) and biomechanical (material properties) aspects of a tissue. Advances in nanotechnology might also made within this problem domain. * scaffold design requires detailed, small-scale substrates (for mechanical support, nutrient delivery). * hybrid protein-carbon structures, or more exotic “biological” solutions (reaction-diffusion models, natural computing, Artificial Life)?

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