Bioorganic chemistry - презентация, доклад, проект скачать

Нажмите для полного просмотра!

Содержание ▲

Вы можете ознакомиться и скачать презентацию на тему Bioorganic chemistry. Доклад-сообщение содержит 25 слайдов. Презентации для любого класса можно скачать бесплатно. Если материал и наш сайт презентаций Mypresentation Вам понравились – поделитесь им с друзьями с помощью социальных кнопок и добавьте в закладки в своем браузере.

Слайды и текст этой презентации

Слайд 1

Описание слайда:

BIOORGANIC CHEMISTRY

Слайд 2

Описание слайда:

Bio-organic chemistry studies organization and features of substances taking part in the processes of life, in connection to study of their biological functions. The main objects of its study are biological polymers (bio-polymers) and bio-regulators. Bio-polymers are high molecular natural compounds, which are structural basis of all living beings, which play a certain role in the processes of life. Bio-polymers include peptides and proteins, polysaccharides (carbohydrates), nucleic acids. This group includes lipids, which are not high molecular combinations by themselves but in the organism they are usually bonded to other bio-polymers. Bio-regulators are compounds, which chemically regulate the exchange of substances. They comprise vitamins, hormones, many synthetic biologically active compounds, including medicines.

Слайд 3

Описание слайда:

The unity of chemical reactions, going on in the organism, is called the exchange of substances or metabolism. Substances, formed in cells, muscles and organs of plants and animals in the process of metabolism, are called metabolites. Metabolism comprises two directions: catabolism and anabolism. Catabolism includes reactions of substances decomposition, which come into the organism with food. As a rule, they go hand-in-hand with oxidation of organic compounds and go with the discharge of energy. Anabolism is a synthesis of complex molecules from more simple, as a result of which formation and renovation of structural elements of a living organism is realized. Metabolic processes come with participation of enzymes, i.e. specific proteins, which are in the organism cells, and play the role of catalysts for bio-chemical processes (bio-catalysts).

Слайд 4

Описание слайда:

HOMOLOGOUS SERIES Rank of similar structured compounds, having similar chemical properties, in which separate members of the rank differ from each other only by the number of -CH2- groups, are called homologues rank (homologous series), and –CH2- group is called homologous diversity. Reactions with the majority of members of homologous rank go in the same way (the exceptions are only the first members of the rank). Thus, if you know chemical reactions of only one member of the rank, you can state with a high degree of possibility, that the similar transformations take place with the rest members of the homologous rank. A general formula can be defined for any homologous rank, which reflects the relation between carbon and hydrogen atoms at members of this rank. Such formula is called general formula of the homologous rank. Thus, CnH2n+2 – formula of alkanes, CnH2n+1OH – is a formula of aliphatic single atom alcohols.

Слайд 5

Описание слайда:

Isomerism of organic compounds If two or more individual substances have the same quantity structure (molecular formula) but are different from each other by the succession of atom bonds or their place in the space, then they are called isomers. If their structure differs, then their chemical and physical properties are also different. Types of isomery are structural (isomers of organization, structure) and stereo-isomery (space). Structural isomery could be of the following types: isomery of the hydrocarbon skeleton (chain isomers), for example, butane and 2-methy-l-propane; isomery of the place of functional groups (or multiple bonds), for example, 1-butanol and 2-butanol; isomers of functional group (interclass), for example, 1-buta-nol and di-ethyl ether. Stereo-isomery is divided into conformation and configuration.

Слайд 6

Описание слайда:

Structural isomerism of organic compounds

Слайд 7

Описание слайда:

Geometric isomerism of organic compounds

Слайд 8

Описание слайда:

Enantiomerism (optical or mirror reflection isomerism)

Слайд 9

Описание слайда:

– there is chiral carbon atom; – there is chiral carbon atom; – there are no elements of symmetry in the molecule. Chiral carbon atom is atoms which has bonds with four different atoms or groups.

Слайд 10

Описание слайда:

Слайд 11

Описание слайда:

Biological activity of enantiomers

Слайд 12

Описание слайда:

Biological activity of enantiomers

Слайд 13

Описание слайда:

Acidity and basicity of organic compounds Bronsted’s acids (proton acids) are neutral molecules or ions, which are able to donate proton (proton donors). Bronsted’s bases are neutral molecules or ions, which are able to accept proton (proton acceptors). Acid and base features are not absolute but relative features of compounds: acid features appear only in the presence of base; and base features appear only in the presence of acid. As a solvent at studying acid-base balance water is usually used.

Слайд 14

Описание слайда:

Using basic properties to get water soluble forms of medicines Basic properties of medicines are used to get their water soluble forms. Interacting with acids compounds with ionic bonds are formed, which are salts well-soluble in water. For example, novocaine for injections is used in the form of hydrochloride.

Слайд 15

Описание слайда:

Acid-base properties of substances and their ways of introduction into organism

Слайд 16

Описание слайда:

Types of reactions in Organic chemistry Organic reactions are classified according to the following principles: 1. Electron nature of reagents. 2. Number of particle change due to reaction. 3. Panial (additional) principles. 4. Mechanism of elementary reaction stage.

Слайд 17

Описание слайда:

According to electron nature of reagents reactions are subdivided into: nucleophilic, electrophilic and free radical Free radicals are electroneutral particles which have non-shared electron, for example, Cl, NO2. Free radical reactions are typical of alkanes. Electrophilic reagents are cations or molecules which in itself or in the presence of catalyst have high affinity to electron pair or negatively charged molecule centres. They include cations H+, Cl+, +NO2, +SO3H, R+ and molecules with free orbitals AlCl3, ZnCl2 и т.п. Electrophilic reactions are typical of alkenes, alkanynes, aromatic compounds (addition on the place of the double bond, proton substitution). Nucleophilic reagents are anions or molecules which have centres of higher electron density. They include anions and moleculs as HO-, RO-, Cl-, Br-, RCOO-, CN-, R-, NH3, C2H5OH, etc.

Слайд 18

Описание слайда:

According to number of particle change there are substitution, addition, elimination and degradation, According to number of particle change there are substitution, addition, elimination and degradation, isomerization

Слайд 19

Описание слайда:

Reaction classification according to panial principles Reaction classification according to panial principles

Слайд 20

Описание слайда:

Poly-functional compounds contain several same functional groups. Poly-functional compounds contain several same functional groups. Hetero-functional compounds contain several different functional groups. Hetero-poly-functional compoundsные contain same and different functional groups.

Слайд 21

Описание слайда:

Each group at poly- and hetero-functional compounds can participate at the same reactions as well as corresponding group at mono-functional compounds Each group at poly- and hetero-functional compounds can participate at the same reactions as well as corresponding group at mono-functional compounds

Слайд 22

Описание слайда:

Characteristic properties of poly- and hetero-functional compounds A lot of properties (amphoteric character) Increase or decrease of some properties in comparison to mono-functional compounds (if ОН, SH, СООН groups are at the structure of the molecule then it leads to acidic property increase, if amino groups are at the molecule NH2, NH, it leads to basic property increase. If there is additional electron acceptor group near acid centre then acid property is increased; If there is electron acceptor substitute then nucleophilic reactions are facilitated and electrophilic reaction rate is slower New specific properties appear