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Вы можете ознакомиться и скачать презентацию на тему Tissue repair. Regeneration and Reparation. Доклад-сообщение содержит 13 слайдов. Презентации для любого класса можно скачать бесплатно. Если материал и наш сайт презентаций Mypresentation Вам понравились – поделитесь им с друзьями с помощью социальных кнопок и добавьте в закладки в своем браузере.

Слайды и текст этой презентации

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Tissue Repair 212- b group O’RMONOV NE’MATJON

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Tissue Repair may start early after tissue damage regeneration by parenchymal cells of the same type reparation replacement by connective tissue (fibrosis) result - scar

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Regeneration and Reparation regeneration restoration of normal structure and function persistence of supportive „tissue skeleton“ necessary BM of epithelia reticulin frame in liver reparation restoration of normal shape x function is impaired or lost parenchyma replaced by fibrous tissue

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Tissue types permanent nonproliferative in postnatal life neurons (?), cardiomyocytes (?) stable regeneration as response to injury parenchyma – liver, pancreas, renal tubules mesenchymal cells, endothelium labile continuous regeneration from stem cells (self-renewal) hematopoietic cells in bone marrow surface epithelia – skin, oral cavity, vagina, cervix duct epithelia – salivary glands, pancreas, biliary tract mucosas – GIT, uterus, fallopian tubes, urinary bladder

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Cell-ECM interactions not only cells! EMC plays important role in healing interstitial matrix – by fibroblasts basement membrane – by fibroblast and epithelium components collagen (18 types) – I, III, IV, V; tensile strength elastin (+ fibrillin) – return to normal structure after stress glycoproteins - adhesion, binding ECM to cells (fibronectin, laminin) proteoglycans and hyalouronans – lubrication (gels)

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Cell-ECM interactions ECM function mechanical support determination of cell polarity control of cell growth maintenance of cell proliferation establishment of tissue microenvironments storage of regulatory molecules

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Replacement of necrotic tissue resorption by macrophages dissolution by enzymes replacement by granulation tissue uniform mechanism irrespective of inicial trigger the same microscopic appearance angiogenesis migration and proliferation of fibroblasts deposition of ECM maturation and reorganization

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Granulation tissue new-formed connective tissue, apparent from 3rd day thin-walled capillary vessels fibroblasts loose extracellular matrix stimulation PDGF, VEGF, FGF, TGF, TNF, EGF inhibition INFalfa, prostaglandins, angiostatins control cyclins, cyclin dependent kinases

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Granulation tissue pink soft granular appearance richly vascularized highly cellular myxoid matrix inflammatory cells e.g. surface of wounds, bottom of ulcers

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Angiogenesis neovascularization x vasculogenesis (embryonic process only) highly complex phenomenon angiogenic factors (FGF, VEGF) antiangiogenic factors healing, collateral circulation, tumors

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Fibrosis and Remodeling scar formation fibroblasts myofibroblasts spindle cells of both fibroblastic and smooth muscle phenotype production of collagen fibres wound contraction

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Fibrosis and Remodeling abundant collagen fibres bridging the defect devoid of inflammatory cells reepithelization of surface defect from skin appendages and/or from periphery secondary changes calcification (dystrophic) ossification (metaplastic) remodeling synthesis and degradation of ECM metalloproteinases (MPs), tissue inhibitors of MPs

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Pathological aspects of healing proud flesh (caro luxurians) excessive amount of GT keloid excessive amount of collagen hyaline plaques serous membranes (spleen, pleura)