🗊 Презентация Rotaviruses

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Rotaviruses, слайд №1 Rotaviruses, слайд №2 Rotaviruses, слайд №3 Rotaviruses, слайд №4 Rotaviruses, слайд №5 Rotaviruses, слайд №6 Rotaviruses, слайд №7 Rotaviruses, слайд №8 Rotaviruses, слайд №9 Rotaviruses, слайд №10 Rotaviruses, слайд №11 Rotaviruses, слайд №12 Rotaviruses, слайд №13 Rotaviruses, слайд №14 Rotaviruses, слайд №15 Rotaviruses, слайд №16 Rotaviruses, слайд №17 Rotaviruses, слайд №18 Rotaviruses, слайд №19 Rotaviruses, слайд №20 Rotaviruses, слайд №21
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Слайды и текст этой презентации

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ROTAVIRUSES by WINDA ZULAIHA SHAHABUDIN GROUP 24
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ROTAVIRUSES by WINDA ZULAIHA SHAHABUDIN GROUP 24

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Rotaviruses, слайд №2
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Morphology Family Reoviridae 70-85 nm diameter Nearly spherical icosahedral particle Non-enveloped, double-shelled viruses Wheel-like distinct...
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Morphology Family Reoviridae 70-85 nm diameter Nearly spherical icosahedral particle Non-enveloped, double-shelled viruses Wheel-like distinct appearance under EM

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Genome 11 segments of double-stranded RNA structural viral proteins (VP): outer/inner capsids: VP4 and VP7core: VP2, VP6, VP1, VP3 nonstructural...
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Genome 11 segments of double-stranded RNA structural viral proteins (VP): outer/inner capsids: VP4 and VP7core: VP2, VP6, VP1, VP3 nonstructural proteins (NSP): NSP1-5

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Genome
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Genome

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Classification defined by cross-neutralization with polyclonal antibodies of antigenic specificities (glycoproteins) VP4 antigen: P serotype; 8 human...
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Classification defined by cross-neutralization with polyclonal antibodies of antigenic specificities (glycoproteins) VP4 antigen: P serotype; 8 human rotaviruses VP7 antigen: G serotype; 10 human rotaviruses commonly found strains: P[8]G1; P[8]G3; P[8]G4; and P[4]G2

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Classification
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Classification

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Replication Attached to cell receptors contained sialic acid Internalized and uncoated via endolysosomes Early transcription by viral RNA polymerase...
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Replication Attached to cell receptors contained sialic acid Internalized and uncoated via endolysosomes Early transcription by viral RNA polymerase occurs inside sub-viral particle Resulted in synthesis of (+) mRNAs and are translated in the cytoplasm. Reassortment occurs during Early transcription.

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Replication Secondary transcription occurs in cytoplasm in later infection in a conservative fashion. Uncapped non-polyadenylated transcripts...
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Replication Secondary transcription occurs in cytoplasm in later infection in a conservative fashion. Uncapped non-polyadenylated transcripts Particles assemble in the cytoplasm 6-7 h after infection Budding from the E.R. into internal spaces & are eventually released when the cell lyses.

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Replication
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Replication

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Pathogenesis infect upper two-third of duodenal epithelial cell infectious particles are released to intestinal lumen and undergo further replication...
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Pathogenesis infect upper two-third of duodenal epithelial cell infectious particles are released to intestinal lumen and undergo further replication in distal areas cause severe diarrhea, vomiting and abdominal pain among children 2 days incubation with 3-8 days watery diarrhea death of over 600,000 children annually worldwide

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Pathogenesis
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Pathogenesis

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Epidemiology Primary transmission mode is fecal-oral ingestion of contaminated food or water and contact with contaminated surfaces Annual epidemics...
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Epidemiology Primary transmission mode is fecal-oral ingestion of contaminated food or water and contact with contaminated surfaces Annual epidemics occurring from November to April high rates of illness among infants and children below 2 years old, but mild among adults

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Epidemiology
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Epidemiology

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Epidemiology
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Epidemiology

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Epidemiology
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Epidemiology

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Diagnosis and Treatment Antigen Enzyme Immunoassay (EIA) of stool specimens RT-PCR; not commonly done Non-specific treatment: oral rehydration...
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Diagnosis and Treatment Antigen Enzyme Immunoassay (EIA) of stool specimens RT-PCR; not commonly done Non-specific treatment: oral rehydration therapy to prevent dehydration Intravenous fluid is required in severe infant cases Immunization by vaccines

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Diagnosis and Treatment
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Diagnosis and Treatment

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Rotavirus vaccine Monovalent Vaccines - Live attenuated vaccine derived from nonhuman host rotaviruses such as bovine and rhesus Reassortant Vaccines...
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Rotavirus vaccine Monovalent Vaccines - Live attenuated vaccine derived from nonhuman host rotaviruses such as bovine and rhesus Reassortant Vaccines - animal-human reassortants expressing VP7 proteins used as immunogens such as rhesus-human reassortant or bovine-human reassortant vaccines

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Rotavirus vaccine Production of reassortant tetravalent vaccine with VP7 serotype 1-4 specificity co-infection of RRV with HRV serotype 1,2, and 3...
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Rotavirus vaccine Production of reassortant tetravalent vaccine with VP7 serotype 1-4 specificity co-infection of RRV with HRV serotype 1,2, and 3 safe and immunogenic

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PREVENTION CDC program
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PREVENTION CDC program

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