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The mechanism of DNA deactivation by hydrogen peroxide action, слайд №1

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Вы можете ознакомиться и скачать презентацию на тему The mechanism of DNA deactivation by hydrogen peroxide action. Доклад-сообщение содержит 13 слайдов. Презентации для любого класса можно скачать бесплатно. Если материал и наш сайт презентаций Mypresentation Вам понравились – поделитесь им с друзьями с помощью социальных кнопок и добавьте в закладки в своем браузере.

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The mechanism of DNA deactivation by hydrogen peroxide action

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Hydrogen peroxide molecule

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DNA macromolecule structure

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Atom-atomic potential function method

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Potential parameters

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H2O2 molecule with DNA phosphate group

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Two-component complexes

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Three-component complexes

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Low-frequency DNA vibration spectrum

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Conclusions Changes to the life cell medium structure as a result of ionizing radiation action is analyzed. Dominant role of hydrogen peroxide molecule in this process is determined. Binding energies of complexes of DNA phosphate group with different molecules are estimated. It is determined that hydrogen peroxide in the presence of sodium counterion can form stable complex with DNA phosphate group. Vibration frequencies and living times of these complexes are estimated. It is determined that complex H2O2-DNA is more long-living than the complex H2O-DNA. It is determined that hydrogen peroxide molecules can form a stable long-living complex with DNA which blocks the process of protein-nucleic recognition and genetic information transition. This may be a key mechanism in the ion therapy treatment.